Omeprazole medicine

What are the Side Effects of Omeprazole

Max. D Gray
By Max. D Gray. Updated: December 29, 2025
What are the Side Effects of Omeprazole
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Omeprazole is a proton-pump inhibitor (PPI) medication, a type of drug that reduces the quantity of gastric acid produced by the stomach. It is used to treat gastroesophageal reflux, ulcers, esophagitis, and infections caused by Helicobacter Pylori, a bacterium found in the stomach that can provoke gastritis and ulcers.

Nowadays, many people take Omeprazole, and it is considered one of the most important medications in the basic health system. However, although Omeprazole is very popular and available as a generic medication, its prolonged use in high doses can have contraindications and side effects on our organism. In this OneHowTo article, we explain what the side effects of Omeprazole are.

You may also be interested in: The Best Natural Alternatives to Omeprazole

Steps to follow:

1

First of all, Omeprazole shouldn't be taken as preventive medication. Proton inhibitors are medications with very precise indications that need to be supervised by a specialist. It's necessary that a doctor diagnoses some ailment before starting to take this drug. If you take Omeprazole without a prescription, you need to bear in mind that your dose can't exceed 20 milligrams per day. Anyway, you should inform your doctor about any heartburn you've suffered during the last three months or any of these symptoms: daze, lack of breath, sweating, or dizziness.

People with liver failure can only take between 10 and 20 milligrams per day of this drug. In any case, you must consult your doctor before taking any so you can discard any possible side effects. Make sure you know how long Omeprazole takes to work depending on the reason you are taking it, as you may take longer than expected to notice significant improvements.

If you're allergic or hypersensitive to Omeprazole, to other drugs from the same type, or to its components, you should consult your doctor. You also need to tell them whether you're taking any other medication such as antibiotics, anticoagulants, diuretics, iron supplements, etc.

Moreover, it's crucial to understand that self-medication can mask underlying conditions. For instance, symptoms relieved by Omeprazole might actually be signs of a more serious condition such as Barrett's esophagus or even esophageal cancer, which require different treatments. Therefore, ongoing medical supervision is highly recommended.

What are the Side Effects of Omeprazole - Step 1
2

Besides these counter-indications, the prolonged use without supervision of this drug can cause side effects. It is associated with interstitial nephritis, a disorder that reduces the ability of kidneys to filter debris and additional liquid from our body, which can cause damage to the heart, brain, lungs, and other organs.

In addition to kidney issues, there is emerging evidence suggesting that long-term use of proton pump inhibitors like Omeprazole may increase the risk of chronic kidney disease. This risk underscores the importance of using the medication only when necessary and under medical guidance. Regular monitoring of kidney function tests can help in early detection of potential renal complications.

3

Late studies determine that Omeprazole reduces the absorption of vitamin B12. Gastric acid is essential for the liberation of this vitamin, and when Omeprazole is taken, the secretion of stomach acids is reduced. When this happens, vitamin B12 is not completely absorbed. The lack of vitamin B12 can cause neurologic damage, dementia, anemia, and other complications.

Furthermore, vitamin B12 deficiency can lead to symptoms such as fatigue, weakness, constipation, loss of appetite, and weight loss. It can also cause neurological changes like numbness and tingling in the hands and feet. Maintaining an adequate intake of vitamin B12 through diet or supplements, especially for those on long-term Omeprazole, is advisable to prevent these adverse effects.

What are the Side Effects of Omeprazole - Step 3
4

Hypomagnesaemia is also associated with the excessive use of Omeprazole. It is a disorder in which magnesium levels in blood decrease considerably, and this can produce an insufficient quantity of gastric acids in the stomach. This will make intestinal absorption much more difficult, which will affect the absorption of magnesium.

Low magnesium levels can lead to muscle spasms, irregular heartbeat, and seizures. In severe cases, hypomagnesemia can result in serious cardiovascular issues. It's important for individuals taking Omeprazole for extended periods to have their magnesium levels monitored regularly. Supplementing with magnesium-rich foods or supplements can also be beneficial.

5

Taking Omeprazole also increases the risk of intestinal infections. The function of Omeprazole is to reduce acid secretions, and due to this, bacterial flora can be affected. This can favor the growth of bacteria that can cause infections.

Research indicates that a reduced gastric acid environment can increase susceptibility to gastrointestinal infections such as Clostridium difficile, which can lead to severe diarrhea and colitis. Maintaining a balanced diet and practicing good hygiene can help mitigate some of these risks. Consulting with a healthcare provider about the use of probiotics may also be advantageous in preserving healthy gut flora.

6

Reducing intestinal acid can also alter the absorption of calcium. For this reason, high doses of Omeprazole and long-term treatments can produce a risk of fractures on hips, wrists, and spine, mostly in the elderly. In these cases, it's important to revise the calcium ingestion.

Ensuring adequate calcium intake, either through diet or supplements, becomes crucial, particularly for individuals at risk of osteoporosis. Engaging in regular weight-bearing exercises can also enhance bone density and reduce fracture risk. Regular bone density assessments may be recommended for individuals on prolonged Omeprazole therapy to monitor bone health.

7

Before taking any drug, remember to consult it with your doctor. If you prefer treating heartburn in a more natural way, we recommend you our article the best natural alternatives to Omeprazole.

Exploring lifestyle modifications such as dietary changes, weight management, and stress reduction can also serve as effective strategies in managing acid reflux and related conditions. Incorporating foods like ginger, which has natural anti-inflammatory properties, may provide relief. Always discuss these alternatives with your healthcare provider to ensure they are appropriate for your specific health needs.

This article is merely informative, oneHOWTO does not have the authority to prescribe any medical treatments or create a diagnosis. We invite you to visit your doctor if you have any type of condition or pain.

If you want to read similar articles to What are the Side Effects of Omeprazole, we recommend you visit our Drugs & supplements category.

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3 comments
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Jorge Cayetano Deliot
I am using Omeprazole since two weeks by medical prescription . But now I am getting diarrhea . I would like to know if this is a possible side effects of this medicine.
Thanks
Ruth Hollon
I have been taking Prilosec /Omeprazole for years. After reading this I'm afraid to take it anymore, but I do have acid reflux. So I am going to look for something natural.
Max. D Gray
Hi Ruth, if you're looking for natural alternatives to Omeprazole you might find this article interesting: http://health.onehowto.com/article/the-best-natural-alternatives-to-omeprazole-2223.html
However, we always recommend to check with your doctor first before leaving any medication.
cuckoo bird
taken for years ok. Sometimes get heartburn anyway lol
Liza macias
I have been taken this now for my gut as on pain killers at night and three times a day ,,the only effect I have suffered is numb fingers which I will be going to see about if this is to do with blood or circulation I certainly know I never had this problem since on thus drug !! What do I take insted ?.
Max. D Gray
Hi Liza, take a look at this article in which we list some of the best natural alternatives to Omeprazole: http://health.onehowto.com/article/the-best-natural-alternatives-to-omeprazole-2223.html
Try switching Omeprazole for one of these natural remedies and see if your fingers get better. Hope this helps.
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What are the Side Effects of Omeprazole